Abnormal pulmonary hemodynamics during exercise is associated with exercise capacity in COPD.

ABSTRACT:

Background

Pulmonary hypertension (PH) is a frequent complication in COPD and it is associated with decreased exercise capacity and poor prognosis. We hypothesized that even in COPD patients without significant PH at rest, abnormal pulmonary hemodynamics during exercise affect exercise capacity.

Methods

Consecutive COPD patients with clinically indicated right heart catheterization and resting mean pulmonary arterial pressure (mPAP) < 25 mmHg and age- and sex-matched controls with the same limits of pulmonary hemodynamics but no chronic lung disease who underwent clinical work-up including invasive hemodynamic assessment during exercise, were retrospectively analyzed. Chi-square tests were used to evaluate differences between groups for categorical data and Fisher's exact te

SUBMITTER: Sassmann T 

PROVIDER: S-EPMC9733173 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature