Treatment with aripiprazole once-monthly injectable formulation is effective in improving symptoms and global functioning in schizophrenia with and without comorbid substance use - a post hoc analysis of the ReLiAM study.

ABSTRACT:

Background

ReLiAM, Real-Life Assessment of Abilify Maintena, was the first reported long-term prospective non-interventional study for patients with schizophrenia treated with aripiprazole once-monthly injectable formulation (AOM) under real-life conditions. ReLiAM's primary aim was to evaluate the evolution of global functional status in patients treated with AOM for 12 months in Canada.

Methods

The objective of this post hoc analysis of the ReLiAM study is to investigate the treatment effects of real-life use of AOM over a 1-year period in the subgroup of patients with reported substance use compared with patients without substance use.

Results

The results of this post hoc analysis demonstrate that treatment with AOM for 12 months in patients with schizophrenia was

SUBMITTER: Margolese HC 

PROVIDER: S-EPMC9733174 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature