Single-cell profiles reveal tumor cell heterogeneity and immunosuppressive microenvironment in Waldenstrom macroglobulinemia.

ABSTRACT:

Background

Waldenström macroglobulinemia (WM) is a rare and incurable indolent B-cell malignancy. The molecular pathogenesis and the role of immunosuppressive microenvironment in WM development are still incompletely understood.

Methods

The multicellular ecosystem in bone marrow (BM) of WM were delineated by single-cell RNA-sequencing (scRNA-seq) and investigated the underlying molecular characteristics.

Results

Our data uncovered the heterogeneity of malignant cells in WM, and investigated the kinetic co-evolution of WM and immune cells, which played pivotal roles in disease development and progression. Two novel subpopulations of malignant cells, CD19⁺CD3⁺ and CD138⁺CD3⁺, co-expressing T-cell marker genes were identified a

SUBMITTER: Sun H 

PROVIDER: S-EPMC9733185 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature