Stratification of COPD patients towards personalized medicine: reproduction and formation of clusters.

ABSTRACT:

Background

The global initiative for chronic obstructive lung disease (GOLD) 2020 emphasizes that there is only a weak correlation between FEV₁, symptoms and impairment of the health status of patients with chronic obstructive pulmonary disease (COPD). Various studies aimed to identify COPD phenotypes by cluster analyses, but behavioral aspects besides smoking were rarely included.

Methods

The aims of the study were to investigate whether (i) clustering analyses are in line with the classification into GOLD ABCD groups; (ii) clustering according to Burgel et al. (Eur Respir J. 36(3):531-9, 2010) can be reproduced in a real-world COPD cohort; and (iii) addition of new behavioral variables alters the clustering outcome. Principal component and hierarchical cluster a

SUBMITTER: van Zelst CM 

PROVIDER: S-EPMC9733189 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature