Altered DNA methylation of CYP2E1 gene in schizophrenia patients with tardive dyskinesia.

ABSTRACT:

Background

About 20-30% of patients with schizophrenia develop tardive dyskinesia (TD). Oxidative stress is one potential causes of TD. CYP2E1 is considered as an oxidative stress-related gene, however, no study has been reported on the DNA methylation levels of the CYP2E1 in schizophrenia or TD.

Methods

A total of 35 schizophrenia patients with TD, 35 schizophrenia patients without TD (NTD), and 35 health controls (HCs) were collected in Beijing, China. DNA was extracted from peripheral blood samples. The promoter methylation levels of CYP2E1 were detected using pyrosequencing. The generalized linear model (GLM) was used to examine the methylation levels of three CpG sites among three diagnostic groups (TD vs. NTD vs. HC).

Results

The average methylation levels were

SUBMITTER: Zhang P 

PROVIDER: S-EPMC9733323 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature