PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry.

ABSTRACT:

Background

Prostate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. Men of African ancestry are at an increased risk of PrCa; however, current polygenic risk score (PRS) models are based on European ancestry groups and may not be broadly applicable. The objective of this study was to construct an African ancestry-specific PrCa PRS (PRState) and evaluate its performance.

Methods

African ancestry group of 4,533 individuals in ELLIPSE consortium was used for discovery of African ancestry-specific PrCa SNPs. PRState was constructed as weighted sum of genotypes and effect sizes from genome-wide association study (GWAS) of PrCa in African ancestry group. Performance was evaluated using ROC-AUC analysis.

Results

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SUBMITTER: Pagadala MS 

PROVIDER: S-EPMC9733391 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature