Combining drug salt formation with amorphous solid dispersions - a double edged sword.

ABSTRACT: Glass transition temperature (T_g) is important for amorphous compounds because it can have implications on their physical and chemical stability. With drugs that possess ionizable acidic or basic groups, salt formation is a potential strategy to reduce re-crystallization tendency through T_g elevation. While salt formation has been reported to impact re-crystallization tendency, it is not known if this holds true for all drugs and if it is useful in the context of amorphous solid dispersion (ASD) formulations. In addition, little information on the impact of salt formation on drug release performance of ASD is available. Herein, the influence of salt formation and T_g elevation on the release performance of lumefantrine (T_g = 19.7 °C) when formulat

SUBMITTER: Hiew TN 

PROVIDER: S-EPMC9733678 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature