Plasma neurofilament light as blood marker for poor brain white matter integrity among middle-aged urban adults.

ABSTRACT: Plasma neurofilament light chain (NfL)'s link to dementia may be mediated through white matter integrity (WMI). In this study, we examined plasma NfL's relationships with diffusion tensor magnetic resonance imaging markers: global and cortical white matter fractional anisotropy (FA) and trace (TR). Plasma NfL measurements at 2 times (v₁: 2004-2009 and v₂: 2009-2013) and ancillary dMRI (v_scan: 2011-2015) were considered (n = 163, mean time v₁ to v_scan = 5.4 years and v₂ to v_scan: 1.1 years). Multivariable-adjusted regression models, correcting for multiple-testing revealed that, overall, higher NfL_v1 was associated with greater global TR (β ± SE: +0.0000560 ± 0.0000186, b = 0.27, p = 0.003, q = 0.012), l

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC9733693 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature