Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies.

ABSTRACT: To combat the COVID-19 pandemic, potential therapies have been developed and moved into clinical trials at an unprecedented pace. Some of the most promising therapies are neutralizing antibodies against SARS-CoV-2. In order to maximize the therapeutic effectiveness of such neutralizing antibodies, Fc engineering to modulate effector functions and to extend half-life is desirable. However, it is critical that Fc engineering does not negatively impact the developability properties of the antibodies, as these properties play a key role in ensuring rapid development, successful manufacturing, and improved overall chances of clinical success. In this study, we describe the biophysical characterization of a panel of Fc engineered ("TM-YTE") SARS-CoV-2 neutralizing antibodies, the same Fc modific

SUBMITTER: Dippel A 

PROVIDER: S-EPMC9733695 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature