Metabolism of [1,6-¹³ C]glucose in the cerebellum of 18-day-old rats: Comparison with cerebral metabolism.

ABSTRACT: There is little information on metabolism in developing cerebellum despite the known importance of this region in cognition and motor tasks. Ex vivo ¹ H- and ¹³ C-NMR spectroscopy were used to determine metabolism during late postnatal development in cerebellum and cerebrum from 18-day-old rat pups after intraperitoneal (i.p.) injection of [1,6-¹³ C]glucose. The concentration of several metabolites in cerebellum was distinctly different than cerebrum; alanine, glutamine, creatine and myo-inositol were higher in cerebellum than cerebrum, the concentrations of lactate, GABA, aspartate and N-acetylaspartate (NAA) were lower in cerebellum than in cerebrum, and levels of glutamate, succinate, choline and taurine were similar in both brain regions. The incorporat

SUBMITTER: Ferreira GC 

PROVIDER: S-EPMC9733799 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature