Multiscale compression-induced restructuring of stacked lipid bilayers: From buckling delamination to molecular packing.

ABSTRACT: Lipid membranes in nature adapt and reconfigure to changes in composition, temperature, humidity, and mechanics. For instance, the oscillating mechanical forces on lung cells and alveoli influence membrane synthesis and structure during breathing. However, despite advances in the understanding of lipid membrane phase behavior and mechanics of tissue, there is a critical knowledge gap regarding the response of lipid membranes to micromechanical forces. Most studies of lipid membrane mechanics use supported lipid bilayer systems missing the structural complexity of pulmonary lipids in alveolar membranes comprising multi-bilayer interconnected stacks. Here, we elucidate the collective response of the major component of pulmonary lipids to strain in the form of multi-bilayer stacks supported o

SUBMITTER: Porras-Gomez M 

PROVIDER: S-EPMC9733850 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature