Maternal early-pregnancy body mass index-associated metabolomic component and mental and behavioral disorders in children.

ABSTRACT: Maternal pre-pregnancy obesity and/or higher body mass index (BMI) have been associated with neurodevelopmental and mental health adversities in children. While maternal metabolomic perturbations during pregnancy may underpin these associations, the existing evidence is limited to studying individual metabolites, not capturing metabolic variation specific to maternal BMI, and not accounting for the correlated nature of the metabolomic measures. By using multivariate supervised analytical methods, we first identified maternal early-pregnancy BMI-associated metabolomic component during pregnancy. We then examined whether this component was associated with mental and behavioral disorders in children, improved the prediction of the child outcomes over maternal BMI, and what proportion of the e

SUBMITTER: Girchenko P 

PROVIDER: S-EPMC9734035 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature