Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior.

ABSTRACT: Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerable comorbidity with MD. Recently, CREB-regulated transcription coactivator 1 (CRTC1), a regulator of brain metabolism, was proposed as a promising factor to understand this relationship. Searching for imaging biomarkers and associating them with pathophysiological mechanisms using preclinical models can provide significant insight into these complex psychiatric diseases and help the development of personalized healthcare. Here, we used neuroimaging technologies to show that deletion of Crtc1 in mice leads to an imaging fingerprint of hipp

SUBMITTER: Cherix A 

PROVIDER: S-EPMC9734042 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature