Acute and chronic blood serum proteome changes in patients with methanol poisoning.

ABSTRACT: Twenty-four blood serum samples from patients with acute methanol poisoning (M) from the mass methanol poisoning outbreak in the Czech Republic in 2012 were compared with 46 patient samples taken four years after poisoning (S) (overlap of 10 people with group M) and with a control group (C) of 24 samples of patients with a similar proportion of chronic alcohol abuse. When comparing any two groups, tens to hundreds of proteins with a significant change in concentration were identified. Fifteen proteins showed significant changes when compared between any two groups. The group with acute methanol poisoning showed significant changes in protein concentrations for at least 64 proteins compared to the other groups. Among the most important identified proteins closely related to intoxication are

SUBMITTER: Cejnar P 

PROVIDER: S-EPMC9734099 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature