An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies.

ABSTRACT:

Purpose

Oncogene addiction provides important therapeutic opportunities for precision oncology treatment strategies. To date the cellular circuitries associated with driving oncoproteins, which eventually establish the phenotypic manifestation of oncogene addiction, remain largely unexplored. Data suggest the DNA damage response (DDR) as a central signaling network that intersects with pathways associated with deregulated addicting oncoproteins with kinase activity in cancer cells.

Experimental

DESIGN: We employed a targeted mass spectrometry approach to systematically explore alterations in 116 phosphosites related to oncogene signaling and its intersection with the DDR following inhibition of the addicting oncogene alone or in combination with irradiation in MET-, EGFR-, A

SUBMITTER: Orlando E 

PROVIDER: S-EPMC9734221 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature