Tamoxifen Activates Dormant Primordial Follicles in Mouse Ovaries.

ABSTRACT: Our previous study found that 17β-estradiol (E₂) suppresses primordial follicle activation and growth in cultured mouse ovaries. In this study, we administered tamoxifen, an estrogen receptor antagonist, into the abdominal cavity of mice to clarify the relationship between primordial follicle activation and the physiological concentration of E₂ in mouse ovaries. The results showed that tamoxifen promoted primordial follicle activation. Administration of tamoxifen promoted degradation of the extracellular matrix surrounding primordial follicles in the ovaries. Furthermore, tamoxifen decreased the expression of stefin A, an inhibitor of cathepsins that digest some proteins and extracellular matrix, in the ovaries. Mechanical stress produced by the extracellular matrix r

SUBMITTER: Wei W 

PROVIDER: S-EPMC9734234 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature