Bioinformatics identifies predictors of arteriovenous fistula maturation.

ABSTRACT:

Background

Arteriovenous fistulae (AVF) are the preferred access for hemodialysis but still have poor rates of maturation and patency limiting their clinical use. The underlying mechanisms of venous remodeling remain poorly understood, and only limited numbers of unbiased approaches have been reported.

Methods

Biological Gene Ontology (GO) term enrichment analysis and differentially expressed genes (DEG) analysis were performed for three AVF datasets. A microRNA enrichment analysis and L1000CDS² query were performed to identify factors predicting AVF patency.

Results

The inflammatory and immune responses were activated during both early and late phases of AVF maturation, with upregulation of neutrophil and leukocyte regulation, cytokine production, and cyto

SUBMITTER: Liu J 

PROVIDER: S-EPMC9734286 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature