M6A 'writer' KIAA1429 regulates the proliferation and migration of endothelial cells in atherosclerosis.

ABSTRACT: Increasing evidences have illustrated the important role of N⁶-methyladenosine (m⁶A) in atherosclerosis (AS). However, the role of m⁶A modification in AS pathophysiological process is still unknown. Here, the present work tried to investigate the expression and function of m⁶A methyltransferase KIAA1429 in AS pathology and explored its undergoing m⁶A-dependent molecular mechanism. Results indicated that KIAA1429 remarkedly up-regulated in oxidative low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs). KIAA1429 over-expression inhibited the proliferation/migration in ox-LDL-treated HUVECs, while, KIAA1429 knockdown up-regulated the proliferation and migration. Mechanistically, via m⁶A modif

SUBMITTER: Rong J 

PROVIDER: S-EPMC9734602 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature