Adiposity and clinical outcomes in East Asian patients with heart failure and preserved ejection fraction.

ABSTRACT:

Background

Despite the obesity paradox, visceral adiposity is associated with poor clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). However, it remains unclear whether a relationship between visceral fat and clinical outcomes exists in Asian patients with HFpEF, in whom obesity is rare.

Methods

Visceral and subcutaneous adipose tissue (VAT and SAT) volume and area were measured using computed tomography (CT) in 196 HFpEF patients. The primary endpoint was a composite of all-cause mortality or HF hospitalization.

Results

Participants had a normal body mass index (BMI) (22.5 ± 4.4 kg/m²), and obesity (BMI > 30 kg/m²) was rare (4.6 %). The primary outcome was observed in 64 patients during a median follow-up

SUBMITTER: Seki Y 

PROVIDER: S-EPMC9735262 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature