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Edible Pueraria lobata-Derived Exosomes Promote M2 Macrophage Polarization.

ABSTRACT: Pueraria lobata (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that P. lobata plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of P. lobata-derived exosomes (Exos) in isolated mouse macrophages. Our results show that P. lobata-derived Exos shift M1 macrophages toward the M2. These data present that P. lobata and puerarin might exert and enhance anti-inflammatory effects through the activation of exosomes and shifts in macrophage polarization, providing strong evidence for the application of P. lobata as novel an anti-inflammatory therapeutic biomaterial.

SUBMITTER: Wu J 

PROVIDER: S-EPMC9735656 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Edible <i>Pueraria lobata</i>-Derived Exosomes Promote M2 Macrophage Polarization.

Wu Jiaqi J   Ma Xiaoyu X   Lu Yu Y   Zhang Tao T   Du Zuoqin Z   Xu Jin J   You Jingcan J   Chen Ni N   Deng Xin X   Wu Jianbo J  

Molecules (Basel, Switzerland) 20221124 23

<i>Pueraria lobata</i> (known as Gegen) is an edible and medicinal herb that is a nutritious medicine food homology plant in China. Previous studies indicated that <i>P. lobata</i> plays an essential role in controlling cytokines. However, the exact mechanism of the inflammation response is still unknown. In this study, we observed the uptake of <i>P. lobata</i>-derived exosomes (Exos) in isolated mouse macrophages. Our results show that <i>P. lobata</i>-derived Exos shift M1 macrophages toward  ...[more]

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