Dataset Information

Ectopic Tumor VCAM-1 Expression in Cancer Metastasis and Therapy Resistance.

ABSTRACT: Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106) is a membrane protein that contributes critical physiologic functional roles in cellular immune response, including leukocyte extravasation in inflamed and infected tissues. Expressed as a cell membrane protein, VCAM-1 can also be cleaved from the cell surface into a soluble form (sVCAM-1). The integrin α4β1 (VLA-4) was identified as the first major ligand for VCAM-1. Ongoing studies suggest that, in addition to mediating physiologic immune functions, VCAM-1/VLA-4 signaling plays an increasingly vital role in the metastatic progression of various tumors. Additionally, elevated concentrations of sVCAM-1 have been found in the peripheral blood of patients with cancer, suggesting the tumor microenvironment (TME) as the source of sVCAM-1. Furthermore, over-expression of VLA-4 was linked to tumor progression in various malignancies when VCAM-1 was also up-regulated. This review explores the functional role of VCAM-1 expression in cancer metastasis and therapy resistance, and the potential for the disruption of VCAM-1/VLA-4 signaling as a novel immunotherapeutic approach in cancer, including osteosarcoma, which disproportionately affects the pediatric, adolescent and young adult population, as an unmet medical need.

SUBMITTER: VanHeyst KA

PROVIDER: S-EPMC9735769 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Ectopic Tumor VCAM-1 Expression in Cancer Metastasis and Therapy Resistance.

VanHeyst Kristen A KA Choi Sung Hee SH Kingsley Daniel T DT Huang Alex Y AY

Cells 20221204 23

Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106) is a membrane protein that contributes critical physiologic functional roles in cellular immune response, including leukocyte extravasation in inflamed and infected tissues. Expressed as a cell membrane protein, VCAM-1 can also be cleaved from the cell surface into a soluble form (sVCAM-1). The integrin α4β1 (VLA-4) was identified as the first major ligand for VCAM-1. Ongoing studies suggest that, in addition to mediating physiologic immune funct ...[more]

PMID: 36497180

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Dataset Information

Ectopic Tumor VCAM-1 Expression in Cancer Metastasis and Therapy Resistance.

Publications

Ectopic Tumor VCAM-1 Expression in Cancer Metastasis and Therapy Resistance.

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