Induction of Cardiac Pathology: Endogenous versus Exogenous Nrf2 Upregulation.

ABSTRACT: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of the endogenous antioxidant response to reactive oxygen species as well as a controller of Phase II detoxification in response to xenobiotics. This amenity to specific external manipulation exploits the binding affinity of Nrf2 for its constitutive repressor and degradation facilitator Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 (Keap1). Derived from both natural and synthesized origins, these compounds have been extensively tested without definitive beneficial results. Unfortunately, multiple terminated trials have shown a negative side to Nrf2 with regard to cardiac pathologies while animal-based studies have demonstrated cardiomyocyte hypertrophy and heart failure after chroni

SUBMITTER: Mathis BJ 

PROVIDER: S-EPMC9736027 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature