Galectins in Esophageal Cancer: Current Knowledge and Future Perspectives.

ABSTRACT: Esophageal cancer is a disease with poor overall survival. Despite advancements in therapeutic options, the treatment outcome of esophageal cancer patients remains dismal with an overall 5-year survival rate of approximately 20 percent. To improve treatment efficacy and patient survival, efforts are being made to identify the factors that underlie disease progression and that contribute to poor therapeutic responses. It has become clear that some of these factors reside in the tumor micro-environment. In particular, the tumor vasculature and the tumor immune micro-environment have been implicated in esophageal cancer progression and treatment response. Interestingly, galectins represent a family of glycan-binding proteins that has been linked to both tumor angiogenesis and tumor immunosupp

SUBMITTER: Godefa TM 

PROVIDER: S-EPMC9736038 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature