Treatment with EV-miRNAs Alleviates Obesity-Associated Metabolic Dysfunction in Mice.

ABSTRACT: Most cells release extracellular vesicles (EVs) that can be detected circulating in blood. We and others have shown that the microRNA contents of these vesicles induce transcriptomic changes in acceptor cells, contributing to the adjustment of metabolic homeostasis in response to environmental demands. Here, we explore the potential for modulating obesity- and exercise-derived EV-microRNAs to treat the metabolic dysfunction associated with obesity in mice. Treatment with EV-miRNAs alleviated glucose intolerance and insulin resistance in obese mice to an extent similar to that of high-intensity interval training, although only exercise improved cardiorespiratory fitness and decreased body weight. Mechanistically, EV-miRNAs decreased fatty acid and cholesterol biosynthesis pathways in the li

SUBMITTER: Castano C 

PROVIDER: S-EPMC9736074 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature