Ontology highlight
ABSTRACT:
SUBMITTER: Castano C
PROVIDER: S-EPMC9736074 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Castaño Carlos C Meza-Ramos Aline A Batlle Montserrat M Guasch Eduard E Novials Anna A Párrizas Marcelina M
International journal of molecular sciences 20221129 23
Most cells release extracellular vesicles (EVs) that can be detected circulating in blood. We and others have shown that the microRNA contents of these vesicles induce transcriptomic changes in acceptor cells, contributing to the adjustment of metabolic homeostasis in response to environmental demands. Here, we explore the potential for modulating obesity- and exercise-derived EV-microRNAs to treat the metabolic dysfunction associated with obesity in mice. Treatment with EV-miRNAs alleviated glu ...[more]