Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies.

ABSTRACT: A growing number of studies have evidenced non-telomeric functions of "telomerase". Almost all of them, however, investigated the non-canonical effects of the catalytic subunit TERT, and not the telomerase ribonucleoprotein holoenzyme. These functions mainly comprise signal transduction, gene regulation and the increase of anti-oxidative systems. Although less studied, TERC (the RNA component of telomerase) has also been shown to be involved in gene regulation, as well as other functions. All this has led to the publication of many reviews on the subject, which, however, are often disseminating personal interpretations of experimental studies of other researchers as original proofs. Indeed, while some functions such as gene regulation seem ascertained, especially because mechanistic findin

SUBMITTER: Udroiu I 

PROVIDER: S-EPMC9736166 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature