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Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker.

ABSTRACT: Metal-organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn4(μ4-O)(μ-FA)L2] (GR-MOF-8) and [Zn4(μ4-O)L2(H2O)] (GR-MOF-9) (H3L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was investigated against Staphylococcus aureus (SA) and Escherichia Coli (EC) by the agar diffusion method. Both bacteria are among the most relevant human and animal pathogens, causing a wide variety of infections, and are often related with the development of antimicrobial resistances. While both Zn-based materials exhibited antibacterial activity against both strains, GR-MOF-8 showed the highest inhibitory action, likely due to a more progressive Zn release under the tested experimental conditions. This is particularly evidenced in the inhibition of SA, with an increasing effect of GR-MOF-8 with time, which is of great significance to ensure the disappearance of the microorganism.

SUBMITTER: Rojas S 

PROVIDER: S-EPMC9736432 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Metal-organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn<sub>4</sub>(μ<sub>4</sub>-O)(μ-FA)L<sub>2</sub>] (GR-MOF-8) and [Zn<sub>4</sub>(μ<sub>4</sub>-O)L<sub>2</sub>(H<sub>2</sub>O)] (GR-MOF-9) (H<sub>3</sub>L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was invest  ...[more]

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