EPLIN, a Putative Tumour Suppressor in Colorectal Cancer, Implications in Drug Resistance.

ABSTRACT: Colorectal cancer is a serious threat to human health. Poor prognosis and frequently reported drug resistance urges research into novel biomarkers and mechanisms to aid in the understanding of the development and progression of colorectal cancer and to optimise therapeutic strategies. In the current study, we investigated the roles of a putative tumour suppressor, EPLIN, in colorectal cancer. Our clinical colorectal cancer cohort and online databases revealed a downregulation of EPLIN in colorectal cancer tissues compared with normal tissues. The reduced expression of EPLIN was associated with poor clinical outcomes of patients. In vitro cellular function assays showed that EPLIN elicited an inhibitory effect on cellular growth, adhesion, migration and invasion. Utilising a protein microar

SUBMITTER: Zeng J 

PROVIDER: S-EPMC9736569 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature