Tumor-Derived Small Extracellular Vesicles Involved in Breast Cancer Progression and Drug Resistance.

ABSTRACT: Breast cancer is one of the most serious and terrifying threats to the health of women. Recent studies have demonstrated that interaction among cancer cells themselves and those with other cells, including immune cells, in a tumor microenvironment potentially and intrinsically regulate and determine cancer progression and metastasis. Small extracellular vesicles (sEVs), a type of lipid-bilayer particles derived from cells, with a size of less than 200 nm, are recognized as one form of important mediators in cell-to-cell communication. sEVs can transport a variety of bioactive substances, including proteins, RNAs, and lipids. Accumulating evidence has revealed that sEVs play a crucial role in cancer development and progression, with a significant impact on proliferation, invasion, and metas

SUBMITTER: Feng L 

PROVIDER: S-EPMC9736664 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature