Tumour Colonisation of Parvimonas micra Is Associated with Decreased Survival in Colorectal Cancer Patients.

ABSTRACT: Increasing evidence suggests that the gut microbiota may impact colorectal cancer (CRC) development and progression. In this study, the tumour colonisation of two CRC-associated bacteria, Parvimonas micra and Fusobacterium nucleatum, was studied in relation to patient survival in a cohort of 257 CRC patients. Colonisation of P. micra and F. nucleatum was analysed in fresh frozen tumour tissue (n = 112) and in faeces (n = 250) by qPCR. When analysing tumour tissues, both P. micra and F. nucleatum were found to be associated with decreased five-year cancer-specific survival, an association that remained significant in multivariable analysis for P. micra. Furthermore, we found significant associations of high levels of P. micra and F.

SUBMITTER: Lowenmark T 

PROVIDER: S-EPMC9736682 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature