Antigen-Specific T Cells and SARS-CoV-2 Infection: Current Approaches and Future Possibilities.

ABSTRACT: COVID-19, a significant global health threat, appears to be an immune-related disease. Failure of effective immune responses in initial stages of infection may contribute to development of cytokine storm and systemic inflammation with organ damage, leading to poor clinical outcomes. Disease severity and the emergence of new SARS-CoV-2 variants highlight the need for new preventative and therapeutic strategies to protect the immunocompromised population. Available data indicate that these people may benefit from adoptive transfer of allogeneic SARS-CoV-2-specific T cells isolated from convalescent individuals. This review first provides an insight into the mechanism of cytokine storm development, as it is directly related to the exhaustion of T cell population, essential for viral clearance

SUBMITTER: Nova Z 

PROVIDER: S-EPMC9737069 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature