Enhancement of the Protective Activity of Vanillic Acid against Tetrachloro-Carbon (CCl₄) Hepatotoxicity in Male Rats by the Synthesis of Silver Nanoparticles (AgNPs).

ABSTRACT: In the current study, the hepatoprotective activity of vanillic acid, silymarin, and vanillic acid-loaded silver nanoparticles (AgNPs) against CCl₄-induced hepatotoxicity was tested in male rats for four weeks. Thirty male rats were divided into five groups (n = 6). The 1st group was a negative control, the 2nd group was a positive control, the 3rd group was treated with 100 mg/kg b.w. of vanillic acid, the 4th group was treated with 100 mg/kg b.w. of vanillic acid-AgNPs, and the 5th group was treated with 50 mg/kg b.w. of silymarin. The CCl₄-induced hepatic toxicity in the 2nd group was revealed by the liver function and all other biochemical tests. Liver enzymes, bilirubin, lipid peroxidation, lactate dehydrogenase, and interleukin-6 were elevated, whereas, t

SUBMITTER: Alamri ES 

PROVIDER: S-EPMC9737075 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature