Green and Efficient Construction of Chromeno[3,4-c]pyrrole Core via Barton-Zard Reaction from 3-Nitro-2H-chromenes and Ethyl Isocyanoacetate.

ABSTRACT: A regioselective one-pot method for the synthesis of 1-ethyl 2,4-dihydrochromene[3,4-c]pyrroles in 63-94% yields from available 2-phenyl-, 2-trifluoro(trichloro)methyl- or 2-phenyl-2-(trifluoromethyl)-3-nitro-2H-chromenes and ethyl isocyanoacetate through the Barton-Zard reaction in ethanol at reflux for 0.5 h, using K2CO3 as a base, has been developed.

SUBMITTER: Kochnev IA 

PROVIDER: S-EPMC9737169 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature