Myomaker and Myomixer Characterization in Gilthead Sea Bream under Different Myogenesis Conditions.

ABSTRACT: Skeletal muscle is formed by multinucleated myofibers originated by waves of hyperplasia and hypertrophy during myogenesis. Tissue damage triggers a regeneration process including new myogenesis and muscular remodeling. During myogenesis, the fusion of myoblasts is a key step that requires different genes' expression, including the fusogens myomaker and myomixer. The present work aimed to characterize these proteins in gilthead sea bream and their possible role in in vitro myogenesis, at different fish ages and during muscle regeneration after induced tissue injury. Myomaker is a transmembrane protein highly conserved among vertebrates, whereas Myomixer is a micropeptide that is moderately conserved. myomaker expression is restricted to skeletal muscle, while the expre

SUBMITTER: Perello-Amoros M 

PROVIDER: S-EPMC9737248 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature