Beyond Platinum, ICIs in Metastatic Cervical Cancer: A Systematic Review.

ABSTRACT:

Background

Cervical cancer (CC) constitutes the fourth most common tumor among the female population. Therapeutic approaches to advanced CC are limited, with dismal results in terms of survival, mainly after progression to platinum-based regimens. Immune checkpoint inhibitors (ICIs) are remodeling the therapeutic scenario of many solid tumors. The role of ICIs in CC should be addressed. Therefore, we systematically reviewed the latest clinical trials employing ICIs in advanced CC to assess which ICIs have been employed and how ICIs might meet the need for new therapeutic options in terms of efficacy and safety.

Methods

The review was conducted following the PRISMA guidelines. The following efficacy outcomes were specifically collected: overall response rate (ORR), disease co

SUBMITTER: Maiorano BA 

PROVIDER: S-EPMC9737392 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature