Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications.

ABSTRACT: Tellurium was successfully incorporated into proteins and applied to protein structure determination through X-ray crystallography. However, studies on tellurium modification of DNA and RNA are limited. This review highlights the recent development of Te-modified nucleosides, nucleotides, and nucleic acids, and summarizes the main synthetic approaches for the preparation of 5-PhTe, 2'-MeTe, and 2'-PhTe modifications. Those modifications are compatible with solid-phase synthesis and stable during Te-oligonucleotide purification. Moreover, the ideal electronic and atomic properties of tellurium for generating clear isomorphous signals give Te-modified DNA and RNA great potential applications in 3D crystal structure determination through X-ray diffraction. STM study also shows that Te-modifie

SUBMITTER: Chen C 

PROVIDER: S-EPMC9737395 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature