Ontology highlight
ABSTRACT:
SUBMITTER: Miller JA
PROVIDER: S-EPMC9737575 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Miller John A JA Drouet Domenica E DE Yermakov Leonid M LM Elbasiouny Mahmoud S MS Bensabeur Fatima Z FZ Bottomley Michael M Susuki Keiichiro K
International journal of molecular sciences 20221206 23
Myelin forming around axons provides electrical insulation and ensures rapid and efficient transmission of electrical impulses. Disruptions to myelinated nerves often result in nerve conduction failure along with neurological symptoms and long-term disability. In the central nervous system, calpains, a family of calcium dependent cysteine proteases, have been shown to have a role in developmental myelination and in demyelinating diseases. The roles of calpains in myelination and demyelination in ...[more]