Distinct Changes in Calpain and Calpastatin during PNS Myelination and Demyelination in Rodent Models.

ABSTRACT: Myelin forming around axons provides electrical insulation and ensures rapid and efficient transmission of electrical impulses. Disruptions to myelinated nerves often result in nerve conduction failure along with neurological symptoms and long-term disability. In the central nervous system, calpains, a family of calcium dependent cysteine proteases, have been shown to have a role in developmental myelination and in demyelinating diseases. The roles of calpains in myelination and demyelination in the peripheral nervous system remain unclear. Here, we show a transient increase of activated CAPN1, a major calpain isoform, in postnatal rat sciatic nerves when myelin is actively formed. Expression of the endogenous calpain inhibitor, calpastatin, showed a steady decrease throughout the period o

SUBMITTER: Miller JA 

PROVIDER: S-EPMC9737575 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature