Deletion of TNF in Winnie-APC^Min/+ Mice Reveals Its Dual Role in the Onset and Progression of Colitis-Associated Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) is among the best examples for depicting the relationship between inflammation and cancer. The introduction of new therapeutics targeting inflammatory mediators showed a marked decrease in the overall risk of CRC, although their chemopreventive potential is still debated. Specifically, a monoclonal antibody that blocks tumor necrosis factor (TNF), infliximab, increases CRC risk in inflammatory bowel disease patients. To address the axis between TNF and CRC development and progression, we depleted the Tnf from our previously established murine model of colitis-associated cancer (CAC), the Winnie-Apc^Min/+ line. We characterized the new Winnie-APC^Min/+-TNF-KO line through macroscopical and microscopical analyses. Surprisingly,

SUBMITTER: Verna G 

PROVIDER: S-EPMC9737576 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature