Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC9737648 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Wang Qiong Q Pan Ying Y Luo Hongjun H Zhang Yanmei Y Gao Fenfei F Wang Jinzhi J Zheng Jinhong J
Molecules (Basel, Switzerland) 20221205 23
In the design of antineoplastic drugs, quinazolinone derivatives are often used as small molecule inhibitors for kinases or receptor kinases, such as the EGFR tyrosine kinase inhibitor gefitinib, p38MAP kinase inhibitor <b>DQO-501</b>, and BRD4 protein inhibitor <b>PFI-1</b>. A novel and convenient approach for the solid-phase synthesis of dihydroquinazoline-2(1<i>H</i>)-one derivatives was proposed and 19 different compounds were synthesized. Cytotoxicity tests showed that most of the target co ...[more]