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Visible Light Promotes Cascade Trifluoromethylation/Cyclization, Leading to Trifluoromethylated Polycyclic Quinazolinones, Benzimidazoles and Indoles.

ABSTRACT: Efficient visible-light-induced radical cascade trifluoromethylation/cyclization of inactivated alkenes with CF3Br, which is a nonhygroscopic, noncorrosive, cheap and industrially abundant chemical, was developed in this work, producing trifluoromethyl polycyclic quinazolinones, benzimidazoles and indoles under mild reaction conditions. The method features wide functional group compatibility and a broad substrate scope, offering a facile strategy to pharmaceutically produce valuable CF3-containing polycyclic aza-heterocycles.

SUBMITTER: Ma R

PROVIDER: S-EPMC9737949 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Visible Light Promotes Cascade Trifluoromethylation/Cyclization, Leading to Trifluoromethylated Polycyclic Quinazolinones, Benzimidazoles and Indoles.

Ma Ransong R Ren Yuanyuan Y Deng Zhoubin Z Wang Ke-Hu KH Wang Junjiao J Huang Danfeng D Hu Yulai Y Lv Xiaobo X

Molecules (Basel, Switzerland) 20221201 23

Efficient visible-light-induced radical cascade trifluoromethylation/cyclization of inactivated alkenes with CF<sub>3</sub>Br, which is a nonhygroscopic, noncorrosive, cheap and industrially abundant chemical, was developed in this work, producing trifluoromethyl polycyclic quinazolinones, benzimidazoles and indoles under mild reaction conditions. The method features wide functional group compatibility and a broad substrate scope, offering a facile strategy to pharmaceutically produce valuable C ...[more]

PMID: 36500485

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