Visible Light Promotes Cascade Trifluoromethylation/Cyclization, Leading to Trifluoromethylated Polycyclic Quinazolinones, Benzimidazoles and Indoles.

ABSTRACT: Efficient visible-light-induced radical cascade trifluoromethylation/cyclization of inactivated alkenes with CF₃Br, which is a nonhygroscopic, noncorrosive, cheap and industrially abundant chemical, was developed in this work, producing trifluoromethyl polycyclic quinazolinones, benzimidazoles and indoles under mild reaction conditions. The method features wide functional group compatibility and a broad substrate scope, offering a facile strategy to pharmaceutically produce valuable CF₃-containing polycyclic aza-heterocycles.

SUBMITTER: Ma R 

PROVIDER: S-EPMC9737949 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature