Transcriptome Profiling in the Hippocampi of Mice with Experimental Autoimmune Encephalomyelitis.

ABSTRACT: Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), approximates the key histopathological, clinical, and immunological features of MS. Hippocampal dysfunction in MS and EAE causes varying degrees of cognitive and emotional impairments and synaptic abnormalities. However, the molecular alterations underlying hippocampal dysfunctions in MS and EAE are still under investigation. The purpose of this study was to identify differentially expressed genes (DEGs) in the hippocampus of mice with EAE in order to ascertain potential genes associated with hippocampal dysfunction. Gene expression in the hippocampus was analyzed by RNA-sequencing and validated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Gene expression analysis reve

SUBMITTER: Weerasinghe-Mudiyanselage PDE 

PROVIDER: S-EPMC9738199 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature