Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies.

ABSTRACT: Bone metastasis is a common complication of many types of advanced cancer, including breast cancer. Bone metastasis may cause severe pain, fractures, and hypercalcemia, rendering clinical management challenging and substantially reducing the quality of life and overall survival (OS) time of breast cancer patients. Studies have revealed that bone metastasis is related to interactions between tumor cells and the bone microenvironment, and involves complex molecular biological mechanisms, including colonization, osteolytic destruction, and an immunosuppressive bone microenvironment. Agents inhibiting bone metastasis (such as bisphosphate and denosumab) alleviate bone destruction and improve the quality of life of breast cancer patients with bone metastasis. However, the prognosis of these pat

SUBMITTER: Pang L 

PROVIDER: S-EPMC9738274 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature