Ontology highlight
ABSTRACT:
SUBMITTER: Al Madhoun A
PROVIDER: S-EPMC9738758 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Al Madhoun Ashraf A Haddad Dania D Nizam Rasheeba R Miranda Lavina L Kochumon Shihab S Thomas Reeby R Thanaraj Thangavel Alphonse TA Ahmad Rasheed R Bitar Milad S MS Al-Mulla Fahd F
Cells 20221206 23
Caveolin-1 (CAV1) is implicated in the pathophysiology of diabetes and obesity. Previously, we demonstrated an association between the CAV1 rs1997623 C > A variant and metabolic syndrome (MetS). Here, we decipher the functional role of rs1997623 in CAV1 gene regulation. A cohort of 38 patients participated in this study. The quantitative MetS scores (siMS) of the participants were computed. CAV1 transcript and protein expression were tested in subcutaneous adipose tissue using RT-PCR and immunoh ...[more]