How Functional Lipids Affect the Structure and Gating of Mechanosensitive MscS-like Channels.

ABSTRACT: The ability to cope with and adapt to changes in the environment is essential for all organisms. Osmotic pressure is a universal threat when environmental changes result in an imbalance of osmolytes inside and outside the cell which causes a deviation from the normal turgor. Cells have developed a potent system to deal with this stress in the form of mechanosensitive ion channels. Channel opening releases solutes from the cell and relieves the stress immediately. In bacteria, these channels directly sense the increased membrane tension caused by the enhanced turgor levels upon hypoosmotic shock. The mechanosensitive channel of small conductance, MscS, from Escherichia coli is one of the most extensively studied examples of mechanically stimulated channels. Different conformational s

SUBMITTER: Flegler VJ 

PROVIDER: S-EPMC9739000 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature