The Black Box of Cellular and Molecular Events of Plasmodium vivax Merozoite Invasion into Reticulocytes.

ABSTRACT: Plasmodium vivax is the most widely distributed malaria parasite affecting humans worldwide, causing ~5 million cases yearly. Despite the disease's extensive burden, there are gaps in the knowledge of the pathophysiological mechanisms by which P. vivax invades reticulocytes. In contrast, this crucial step is better understood for P. falciparum, the less widely distributed but more often fatal malaria parasite. This discrepancy is due to the difficulty of studying P. vivax's exclusive invasion of reticulocytes, which represent 1-2% of circulating cells. Its accurate targeting mechanism has not yet been clarified, hindering the establishment of long-term continuous in vitro culture systems. So far, only three reticulocyte invasion pathways have been characterised

SUBMITTER: Molina-Franky J 

PROVIDER: S-EPMC9739029 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature