Serum Kynurenic Acid and Kynurenine Are Negatively Associated with the Risk of Adult Moyamoya Disease.

ABSTRACT: Kynurenine (KYN) and kynurenic acid (KYNA) are key intermediate metabolites associated with inflammation and immune responses in the kynurenine pathway. It remains unknown whether KYN or KYNA is associated with the risk of adult moyamoya disease (MMD). The aim of this study was to prospectively investigate the association between serum KYN or KYNA and the risk of adult MMD. The study was conducted from July 2020 to December 2021. We measured serum KYN and KYNA levels for 360 adult MMD patients (259 cases of ischemic MMD, 101 cases of hemorrhagic MMD) and 89 age-sex-matched healthy controls. Clinical and laboratory characteristics were collected from the medical record. After multivariate adjustment, decreased serum KYNA (OR, 0.085; 95% CI, 0.035-0.206; p = 0.000) or KYN (OR, 0.430; 95% CI,

SUBMITTER: Yu X 

PROVIDER: S-EPMC9739245 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature