PH-Dependent Release of Vancomycin from Modularly Assembled Collagen Laminates.

ABSTRACT: To prevent surgical site infections, antibiotics can be released from carriers made of biomaterials, such as collagen, that support the healing process and are slowly degraded in the body. In our labs we have developed collagen laminates that can be easily assembled and bonded on-site, according to medical needs. As shown previously, the asymmetric assembly leads to different release rates at the major faces of the laminate. Since the pH changes during the wound healing and infection, we further examined the effect of an acidic and alkaline pH, in comparison to pH 7.4 on the release of vancomycin from different collagen samples. For this purpose, we used an additively manufactured sample holder and quantified the release by HPLC. Our results show that the pH value does not have any influen

SUBMITTER: Kilb MF 

PROVIDER: S-EPMC9740012 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature