Associations of Genetically Predicted Vitamin B₁₂ Status across the Phenome.

ABSTRACT: Variation in vitamin B₁₂ levels has been associated with a range of diseases across the life-course, the causal nature of which remains elusive. We aimed to interrogate genetically predicted vitamin B₁₂ status in relation to a plethora of clinical outcomes available in the UK Biobank. Genome-wide association study (GWAS) summary data obtained from a Danish and Icelandic cohort of 45,576 individuals were used to identify 8 genetic variants associated with vitamin B₁₂ levels, serving as genetic instruments for vitamin B₁₂ status in subsequent analyses. We conducted a Mendelian randomisation (MR)-phenome-wide association study (PheWAS) of vitamin B₁₂ status with 945 distinct phenotypes in 439,738 individuals from the UK Biobank using thes

SUBMITTER: Dib MJ 

PROVIDER: S-EPMC9740080 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature