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Supramolecular Diversity, Theoretical Investigation and Antibacterial Activity of Cu, Co and Cd Complexes Based on the Tridentate N,N,O-Schiff Base Ligand Formed In Situ.

ABSTRACT: The four new complexes, [Cu(HL1)(L2)Cl] (1), [Cu(HL1)(L1)]∙Cl∙2H2O (2), [Co(L1)2]∙Cl (3) and [Cd(HL1)I2]∙dmso (4), have been prepared by one-pot reactions of the respective chloride or iodide metal salt with a non-aqueous solution of the polydentate Schiff base, HL1, resulted from in situ condensation of benzhydrazide and 2-pyridinecarboxaldehyde, while a ligand HL2, in case of 1, has been formed due to the oxidation of 2-pyridinecarboxaldehyde under reaction conditions. The crystallographic analysis revealed that the molecular building units in 1-4 are linked together into complex structures by hydrogen bonding, resulting in 1D, 2D and 3D supramolecular architectures for 1, 2 and 4, respectively, and the supramolecular trimer for 3. The electronic structures of 1-4 were investigated by the DFT theoretical calculations. The non-covalent interactions in the crystal structures of 1-4 were studied by means of the Hirshfeld surface analysis and the QTAIM theory with a special focus on the C-H⋯Cl bonding. From the DFT/DLPNO-CCSD(T) calculations, using a series of charged model {R3C-H}0⋯Cl- assemblies, we propose linear regressions for assessment of the interaction enthalpy (ΔH, kcal mol-1) and the binding energy (BE, kcal mol-1) between {R3C-H}0 and Cl- sites starting from the electron density at the bond critical point (ρ(rBCP), a.u.): ΔH = -678 × ρ(r) + 3 and BE = -726 × ρ(r) + 4. It was also has been found that compounds 1, 3 and 4 during in vitro screening showed an antibacterial activity toward the nine bacteria species, comprising both Gram-positive and Gram-negative, with MIC values ranging from 156.2 to 625 mg/L. The best results have been obtained against Acinetobacter baumannii MβL.

SUBMITTER: Buvaylo EA

PROVIDER: S-EPMC9740120 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Supramolecular Diversity, Theoretical Investigation and Antibacterial Activity of Cu, Co and Cd Complexes Based on the Tridentate N,N,O-Schiff Base Ligand Formed In Situ.

Buvaylo Elena A EA Nesterova Oksana V OV Goreshnik Evgeny A EA Vyshniakova Hanna V HV Petrusenko Svitlana R SR Nesterov Dmytro S DS

Molecules (Basel, Switzerland) 20221125 23

The four new complexes, [Cu(HL1)(L2)Cl] (1), [Cu(HL1)(L1)]∙Cl∙2H2O (2), [Co(L1)2]∙Cl (3) and [Cd(HL1)I2]∙dmso (4), have been prepared by one-pot reactions of the respective chloride or iodide metal salt with a non-aqueous solution of the polydentate Schiff base, HL1, resulted from in situ condensation of benzhydrazide and 2-pyridinecarboxaldehyde, while a liga ...[more]

PMID: 36500325

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Project description:New Co(II), Ni(II), and Cu(II) complexes were synthesized with the Schiff base ligand obtained by the condensation of sulfathiazole with salicylaldehyde. Their characterization was performed by elemental analysis, molar conductance, spectroscopic techniques (IR, diffuse reflectance and UV-Vis-NIR), magnetic moments, thermal analysis, and calorimetry (thermogravimetry/derivative thermogravimetry/differential scanning calorimetry), while their morphological and crystal systems were explained on the basis of powder X-ray diffraction results. The IR data indicated that the Schiff base ligand is tridentate coordinated to the metallic ion with two N atoms from azomethine group and thiazole ring and one O atom from phenolic group. The composition of the complexes was found to be of the [ML2]∙nH2O (M = Co, n = 1.5 (1); M = Ni, n = 1 (2); M = Cu, n = 4.5 (3)) type, having an octahedral geometry for the Co(II) and Ni(II) complexes and a tetragonally distorted octahedral geometry for the Cu(II) complex. The presence of lattice water molecules was confirmed by thermal analysis. XRD analysis evidenced the polycrystalline nature of the powders, with a monoclinic structure. The unit cell volume of the complexes was found to increase in the order of (2) < (1) < (3). SEM evidenced hard agglomerates with micrometric-range sizes for all the investigated samples (ligand and complexes). EDS analysis showed that the N:S and N:M atomic ratios were close to the theoretical ones (1.5 and 6.0, respectively). The geometric and electronic structures of the Schiff base ligand 4-((2-hydroxybenzylidene) amino)-N-(thiazol-2-yl) benzenesulfonamide (HL) was computationally investigated by the density functional theory (DFT) method. The predictive molecular properties of the chemical reactivity of the HL and Cu(II) complex were determined by a DFT calculation. The Schiff base and its metal complexes were tested against some bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis). The results indicated that the antibacterial activity of all metal complexes is better than that of the Schiff base.

Project description:Three imidazole-derived Schiff base compounds comprising an N-methyl imidazole group coupled to a phenol ring through an imine bond were synthesised. The structures differ by the substituent on the phenol ring at the 4-position: methyl (1), tert-butyl (2) and hydrogen (3). The compounds were synthesised using both a traditional reflux in solvent as well as an environmentally friendly solid-state reaction. Compounds (1)-(3) as well as the hemihydrate of (3) were all studied by single crystal X-ray diffraction. The asymmetric unit of compound (1) consists of two nominally planar molecules linked by hydrogen bonds to form a dimeric supramolecular structure. This dimeric structure was ubiquitous for the anhydrous forms of (1)-(3). The complementary hydrogen bonding motif between the imidazole N atoms and the phenol OH results in a stable 16-membered hydrogen-bonded ring. The asymmetric unit of (3) comprises two symmetry-independent molecules one of which has co-planar imidazole and phenol rings while the other shows a significantly oblique orientation. The hemihydrate of (3) similarly forms extensive hydrogen bonds, though in the form of a water-bridged dimeric structure. The hydrogen bond lengths (D⋯A) for compounds (1)-(3) are relatively short, ranging from 2.662(1) to 2.688(1) Å. DFT was used to understand the relative stability of the monomeric and dimeric species. These showed the hydrogen-bonded supramolecular structures were ca. 101 kJ mol-1 lower in energy than the non-interacting monomers. Scan simulations were used to calculate the total energy of the molecule as a function of phenyl ring rotation and showed why the expected planar configuration for a conjugated π-system was not observed experimentally. The barrier to rotation was found to be relatively low, 7.97(6) kJ mol-1, with the lowest energy conformations subtending dihedral angles of 22.319, 24.265 and 25.319° for molecules (1), (2) and (3), respectively. The electrostatic potential maps are able to succinctly explain the stability of the hydrogen bonds through the partial charges of the interacting atoms. TD-DFT simulations and analysis of the simulated and experimental UV/visible spectra suggest that the dimeric supramolecular structure is a stable species in solution. This was confirmed through 1H NMR titrations and an equilibrium constant of 0.16(5) M-1 was estimated.

Dataset Information

Supramolecular Diversity, Theoretical Investigation and Antibacterial Activity of Cu, Co and Cd Complexes Based on the Tridentate N,N,O-Schiff Base Ligand Formed In Situ.

Publications

Supramolecular Diversity, Theoretical Investigation and Antibacterial Activity of Cu, Co and Cd Complexes Based on the Tridentate N,N,O-Schiff Base Ligand Formed In Situ.

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