Modulation Effects of Fe³⁺, Zn²⁺, and Cu²⁺ Ions on the Amyloid Fibrillation of α-Synuclein: Insights from a FTIR Investigation.

ABSTRACT: Amyloid fibrillation of α-synuclein is implicated in the pathogenesis of Parkinson's disease and heavy metal ions such as Fe³⁺, Zn²⁺, and Cu²⁺ are known to be involved in the process. In this work, we explored the use of FTIR spectroscopy to look into the modulation effects of Fe³⁺, Zn²⁺, and Cu²⁺ on the amyloid fibrillation of α-synuclein. We performed a curve-fitting analysis on the FTIR amide I bands of these α-synuclein fibril systems, namely, the pristine fibril and the fibrils prepared in the presence of Fe³⁺, Zn²⁺, and Cu²⁺. We found that the α-synuclein fibrils under the influences of metal ions all possessed a parallel β-sheet structure, turn structure, and disordered structure, simi

SUBMITTER: Li Y 

PROVIDER: S-EPMC9740228 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature