The Dynamics of Cryptococcus neoformans Cell and Transcriptional Remodeling during Infection.

ABSTRACT: The phenotypic plasticity of Cryptococcus neoformans is widely studied and demonstrated in vitro, but its influence on pathogenicity remains unclear. In this study, we investigated the dynamics of cryptococcal cell and transcriptional remodeling during pulmonary infection in a murine model. We showed that in Cryptococcus neoformans, cell size reduction (cell body ≤ 3 µm) is important for initial adaptation during infection. This change was associated with reproductive fitness and tissue invasion. Subsequently, the fungus develops mechanisms aimed at resistance to the host’s immune response, which is determinant for virulence. We investigated the transcriptional changes involved in this cellular remodeling and found an upregulation of transcripts related to ribosome biogenesis at the beginn

SUBMITTER: Freitas GJC 

PROVIDER: S-EPMC9740611 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature